Wolfson Institute of Preventive Medicine
Calculation of the cost of antenatal screening for Downs Syndrome based on the results of SURUSS (Serum Urine and Ultrasound Screening Study).
 
The costs and rates shown are taken from example A in the SURUSS report. To calculate the cost of screening on the basis of your own unit costs and rates overwrite the required values in the table below and click the button labelled 'Calculate'.
 
 
Please Enter one of the following (the other will be calculated)
Birth Prevalence (nos per 1000) of Down's Syndrome at Term  
Expected No of Down's Syndrome at Mid Trimester Per 100,000 Women  
Please Enter Costs
Reagent Cost of Serum Marker (singleton assay):  
AFP €  
Free ß-hCG* €  
uE3 €  
Inhibin-A €  
PAPP-A €  
Other Costs:    
Nuchal Translucency Measurement €  
Non-reagent Laboratory Costs (per sample collected) €  
Service Costs (computer assisted interpretation and administration) €  
2nd Trimester Diagnostic Test e.g. Amniocentesis €  
1st Trimester Diagnostic Test e.g. CVS €  
Termination of pregnancy €  
Medical Evacuation of products of conception €  
Delivery €  
Please Enter Rates (as percentages)
Uptake of Diagnostic Test in Affected Pregnancies    %
Uptake of Diagnostic Test in Unaffected Pregnancies    %
Uptake of Termination in Affected Pregnancies    %
Fetal Loss Rate Due to Diagnostic Test    %

  
* Using total hCG instead of Free ß-hCG in the second trimester tests or the integrated tests has a negligible effect on the cost estimates. If total hCG is used in the second trimester, enter the price for this; the cost estimates for the combined test will then be inapplicable unless the costs of total hCG and Free ß-hCG are the same.

Cost (€ millions) of screening 100,000 women and diagnosis of screen-positives for selected screening tests according to specified detection rates

  Detection Rate (%)
Screening Test** 75 80 85 90
 
Double (AFP, Free ß-hCG)
Triple (AFP, Free ß-hCG, uE3)
Quadruple (AFP, Free ß-hCG, uE3, Inhibin-A)
Combined (NT, PAPP-A, Free ß-hCG)
Serum Integrated (PAPP-A, Quadruple) at 10 weeks
Serum Integrated (PAPP-A, Quadruple) at 11 weeks
Integrated (NT, PAPP-A, Quadruple)

Cost (€ thousands) per Down's syndrome pregnancy detected for selected screening tests according to specified detection rates

  Detection Rate (%)
Screening Test** 75 80 85 90
 
Double (AFP, Free ß-hCG)
Triple (AFP, Free ß-hCG, uE3)
Quadruple (AFP, Free ß-hCG, uE3, Inhibin-A)
Combined (NT, PAPP-A, Free ß-hCG)
Serum Integrated (PAPP-A, Quadruple) at 10 weeks
Serum Integrated (PAPP-A, Quadruple) at 11 weeks
Integrated (NT, PAPP-A, Quadruple)

** All tests include maternal age and, where appropriate, Free ß-hCG is used in the second trimester
 
Website Manager: Wolfson Institute Website Manager Back to Currency Select CEPM Home Page
 
  [ Return to top of page ]