Wolfson Institute of Preventive Medicine

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Randomised trial of H Pylori screening for the prevention of stomach cancer

Background and study aims

Helicobacter pylori is a bacterial infection that increases the risk of stomach cancer. The aim of this study is to find out whether screening for and eradicating H. pylori infection in healthy middle aged people can reduce the subsequent incidence of stomach cancer.

Who participated?
62,454 men aged 35-69 and women aged 45-69 who attended a Bupa Wellness Centre for a health screen between July 1997 and January 2006.

What did the study involve?
Participants were randomly allocated to one of two groups. Participants in one group were tested for H. pylori and, if found to be infected, were offered a one-week course of drug treatment to eradicate the infection (oral metronidazole, clarithromycin and lansoprazole). Participants in the other group did not receive any screening or treatment. Death certificate and cancer registrations are received from NHS Digital on all participants to assess the incidence of deaths from stomach cancer.

When is the study starting and how long is it expected to run for?
April 1997 to January 2030

Cancer Research UK (CRUK) are currently funding this follow-up stage of the trial.

To see the original patient information leaflet please click here

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