Wolfson Institute of Preventive Medicine

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Centre for Cancer Prevention

Funding Body:  Cancer Research UK


Early detection of oesophageal cancer improves outcomes, however the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett's oesophagus (BE) is not clear.
The BEST3 trial is evaluating whether systematic, non-endoscopic investigation of patients on long-term medication for heartburn and acid reflux symptoms is an effective triage test to increase the diagnosis of BE without unduly burdening the clinical service.
The multi-site cluster-randomised controlled trial will evaluate the ability of the CytospongeTM-TFF3 test to identify BE among patients who do not meet guidelines for urgent referral. The study will aim to recruit over 9,000 patients in 150 practices.
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