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Wolfson Institute of Preventive Medicine

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Epidemiology and prevention of congenital anomalies

We provide statistical expertise on the analysis of data on congenital anomalies with recent work including the development of a European reproductive pharmacovigilance system.

We are funded by Public Health England to provide national data on the epidemiology of all congenital anomalies in England and Wales.

Overview

We are a source of national data on the epidemiology of all congenital anomalies in England and Wales. We are funded by Public Health England to run the National Down Syndrome Cytogenetic Register (NDSCR) and to produce national reports collating data on all congenital anomalies occurring in England and Wales collected by BINOCAR registers.

Professor Sir Nicholas Wald ran the MRC vitamin trial that demonstrated that folic acid supplementation prior to pregnancy could prevent Neural Tube Defects.

We continue to provide evidence on both the use of supplementation plus the prevalence of NTDs to demonstrate that folic acid supplementation is not effective and that mandatory fortification should be adopted in the UK.

Methods of surveillance of congenital anomalies are being developed in collaboration with EUROCAT (European Congenital Anomaly Registers) and a European reproductive pharmacovigilance system is being developed in collaboration with euromedicat.

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