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Wolfson Institute of Preventive Medicine

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Cardiovascular disease and diabetes prevention

We originated the Polypill concept in the prevention of cardiovascular disease and have undertaken trials demonstrating its effectiveness.

We quantified the relationship between salt intake and cardiovascular disease across the population.
Britain’s leading advocacy group into salt and sugar intake reduction is based in our centre. Beat Diabetes Calculator

Overview

We have completed one randomised crossover trial on the Polypill, confirming the predicted efficacy in lowering blood pressure and cholesterol.

We are planning to undertake two further trials, in collaboration with colleagues in the William Harvey Research Institute, to obtain market authorisation.

We are conducting a large scale study in collaboration with General Practice, to demonstrate the efficacy and feasibility of child-parent screening for familiar hypercholesterolemia.

We have completed an important trial showing the value of preventive angioplasty in myocardial infarction.

The Centre houses data on one of the largest population cohort studies in the world, the BUPA study, which has produced a large number of publications in relation to smoking, nutrition, factors, and prostate-specific antigens.

We have completed detailed analytical studies quantifying the relationship between salt intake and blood pressure and cardiovascular disease and between blood cholesterol and cardiovascular disease in the general population.

The Centre houses Britain’s leading advocacy group into salt and sugar intake reduction and is conducting work into assessing the public health benefits of fiscal measures to reduce the consumption of specified food components.

The Polypill concept, developed by scientists in the Centre, offers a simple and effective method of preventing most heart attacks and strokes. The Polypill papers are available here.

We conducted a comprehensive mata-analysis of the Use of blood pressure lowering drugs in the prevention of cardiovascular disease (BMJ, 2009). A meta-analysis audit trail of the studies used in this publication is available here.

We have quantified the large impact of a person's weight on the incidence of diabetes in The British Journal of General Practice and produced an on-line "Beat Diabetes Calculator" to estimate how much weight a person needs to lose to avoid their excess risk of diabetes due to their weight.

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