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20 March 2015

TOMMY Trial results: improving breast cancer screening in the UK

, Posted in General News, Publications

TOMMY Trial results: improving breast cancer screening in the UK

Professor Stephen Duffy is continuing his exceptional research track record in cancer epidemiology, screening and policy.

This new publication reports the results of the TOMMY trial that tested the effectiveness of adding a 3D imaging technique to standard mammography.



Screening for breast cancer

Breast screening is currently recognised as the best way to detect early-stage breast cancer and reduce deaths as a result of early diagnosis and treatment. In a standard breast screening radiograph (mammogram), overlapping breast tissue may hide some cancers (false negatives) or make normal tissue appear abnormal (false positives). A newer technique called digital breast tomosynthesis (DBT) takes a series of low-dose radiographs of the breast that are processed by a computer to construct a 3-dimensional DBT image. This allows abnormalities in the breast be seen more clearly and could make it easier to see small cancers and decrease the risk of 'false alarms'.

mammogram dense

Mammogram of dense breast tissue 
(Wikimedia commons)

The TOMMY trial

The study compared the accuracy of reading the following screening combination techniques to identify breast cancer:

(1) a 2D mammogram 
(2) a 2D mammogram together with a DBT, and 
(3) a synthetic 2D mammogram with a DBT

Data from 7061 cases were analysed: 6021 cases from women (47–73 years) recalled after routine screening for further tests, and 1040 cases from women (40–49 years) with a family history of breast cancer attending their annual breast screenings.

The results of the study showed that combining 2D + DBT (2) or synthetic 2D + DBT (3) gives a small increase in the number of cancer cases detected and could help minimise the number of women recalled for unnecessary tests, (false positives), which could also reduce healthcare costs and patient anxiety.

Further research is still needed into the feasibility of implementing DBT in our screening programme, including modelling outcomes and mortality, as well as comparison of 2D and synthetic 2D imaging for different lesion types.

This project was funded by the NIHR Health Technology Assessment programme


The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme--a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone.
Gilbert FJ, Tucker L, Gillan MG, Willsher P, Cooke J, Duncan KA, Michell MJ, Dobson HM6, Lim YY, Purushothaman H, Strudley C, Astley SM, Morrish O, Young KC, Duffy SW. Health Technol Assess. (2015) (4):i-xxv, 1-136. PMID: 25599513

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