Wolfson Institute of Preventive Medicine

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BUPA Cohort

The BUPA cohort study was set up to look at risk factors for cancer and mortality, with an emphasis on the risks of smoking. 22,000 men aged 35-64 years who attended the British United Provident Association (BUPA) medical center in London for a comprehensive medical examination between 1975 and 1982 were asked if they wished to take part in a research project that would use their named data. If so they were asked to complete an additional questionnaire and provide an additional blood sample for research purposes.

The comprehensive medical examination also included a physical examination, lung function tests, chest X rays, an electrocardiogram and blood tests. Data from all these tests has been stored for research purposes at the Wolfson Institute of Preventive Medicine. The blood samples have been stored as serum samples in freezers. The men have been flagged at NHSIC and information on mortality and cancer is received quarterly. All data is stored on a secure fire-wall protected server which can be accessed only via passwords by three members of staff. No identifying information is released.

Research Results from BUPA Cohort

Over 40 papers have been published in main line medical journals. The areas of research covered have included the health effects of active and passive smoking, screening, cancer and nutrition, cancer and infection, serum cholesterol in relation to ischaemic heart disease and cancer, apolipoproteins and IHD, blood pressure and stroke, cardiovascular screening and osteoporosis. (see Publications)

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