Graham MacGregor, MA, MB, B.Chir
Professor of Cardiovascular Medicine
Centre for Environmental and Preventive Medicine
Tel: +44 (0) 20 7882 6217
Graham MacGregor is Professor of Cardiovascular Medicine at the Wolfson Institute of Preventive Medicine (Barts & The London) and Honorary Consultant Physician at St George's Hospital, London.
He is a visiting Professor at St George's Hospital Medical School, London.
Originally trained as a nephrologist and became interested in blood pressure control mechanisms, particularly related to the renin-angiotensin system, the mechanisms whereby salt puts up blood pressure.
- Salt and Potassium Intake
- Several key studies were done on salt to look at the effect of salt intake on blood pressure, and in particular reducing it, and into the politics of salt reduction.
In 1996 he set up an action group on salt, Consensus Action on Salt and Health, to try and get the food industry to add less salt to the food and thereby get a reduction in salt intake. This action group was successful and resulted in the Food Standards Agency taking on the task of salt reduction. The UK is now leading the world in salt reduction.
In 2005 he set up the international action group on salt, World Action on Salt and Health, which now has over 500 members in 98 countries. The group has been successful in spreading the message about salt worldwide, and also convincing the World Health Organisation and the World Health Assembly in the prevention of NCDs, that salt reduction is a very cost-effective public health measure.
In 2000 he set up the Blood Pressure Association (now Blood Pressure UK), a patients association for high blood pressure to get better information to patients and to lobby for better treatment of high blood pressure in the UK. This has been very successful in the UK, and won the Charity of the Year Award in 2008. It also runs an annual Know Your Numbers Campaign where more than 250,000 people have their blood pressure measured throughout the UK.
He sat for many years on the World Hypertension League board where he remains as an advisor on salt reduction, and also serves as President of the British Hypertension Society.
- A school based education programme to reduce salt intake in children and their families
- Consensus Action on Salt and Health (CASH)
- World Action on Salt and Health (CASH)
- A model for good health-Modelling the effect of salt reduction on future burdens of disease in 30 countries
- Maintenance of blood pressure by the renin-angiotensin system in normal man.
- Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension.
- Double-blind randomised trial of modest salt restriction in older people.
- Importance of salt in determining blood pressure in children: meta-analysis of controlled trials.
- Fruit and vegetable consumption and stroke: meta-analysis of cohort studies.
- Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials.
- Surveys of the salt content in UK bread: progress made and further reductions possible.
- Plasma sodium stiffens vascular endothelium and reduces nitric oxide release.
- Plasma sodium concentration rapidly changes blood pressure during haemodialysis.